Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats

Gris, P.; Tighe, A.; Thawer, S.; Hemphill, A.; Oatway, M.; Weaver, L.; Dekaban, G.A.; Brown, A. (2009). Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats. Journal of neuroimmunology, 209(1-2), pp. 104-13. Amsterdam: Elsevier 10.1016/j.jneuroim.2009.02.002

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Acute administration of a mononclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. We have profiled gene expression in anti-CD11d and isotyped-matched control mAb-treated rats after SCI. Microarray analysis demonstrated reduced expression of pro-inflammatory cytokines and increased expression of inflammatory mediators that promote wound healing and the expression of scar proteins predicted to improve nerve growth. These changes in gene expression may reflect changes in the types of macrophages that populate the lesions in anti-CD11d mAb-treated rats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew

ISSN:

0165-5728

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

17 Mar 2015 22:53

Publisher DOI:

10.1016/j.jneuroim.2009.02.002

Web of Science ID:

000266299900012

URI:

https://boris.unibe.ch/id/eprint/38336 (FactScience: 221171)

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