The keratinocyte in epidermal renewal and defence

Suter, M.M.; Schulze, K.; Bergman, W.; Welle, M.; Roosje, P.; Muller, E.J. (2009). The keratinocyte in epidermal renewal and defence. Veterinary dermatology, 20(5-6), pp. 515-32. Oxford: Blackwell Science 10.1111/j.1365-3164.2009.00819.x

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Traditionally, keratinocytes have been considered inert constituents of the multilayered epidermis. Today's understanding has fundamentally changed. The keratinocyte is now recognized as an active player in epidermal renewal with key functions in the skin's immune defence. Under homeostatic conditions, keratinocyte progenitor cells are believed to divide symmetrically or asymmetrically, that is they continue to proliferate or go on to terminally differentiate and build up the overlaying epidermis. The fine-tuned process of epidermal renewal relies on an extraordinary network of signalling cascades which are governed by keratinocyte-receptor interactions with the environment through paracrine and autocrine circuits. Opposing this coordinated homeostatic process are signals of wounding and inflammation. They alter the fate of the keratinocyte and its response to the environment through changes in adhesion molecules and surface receptors, in addition to triggering an immediate inflammatory keratinocyte response in terms of secretion of cytokines, chemokines and antimicrobial peptides. If uncontrolled, the fundamental changes imposed by wounding and inflammation upon the homeostatic programme can lead to severe skin lesions including chronic inflammatory disorders. This review will describe the current knowledge of the regulatory signalling network which allows the keratinocyte to actively impact both epidermal homeostasis and the inflammatory response.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology
UniBE Contributor:	Bergmann, Wilhelmina, Welle, Monika Maria, Roosje Hasler, Pieternella, Müller, Eliane Jasmine
ISSN:	0959-4493
Publisher:	Blackwell Science
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:25
Last Modified:	02 Mar 2023 23:23
Publisher DOI:	10.1111/j.1365-3164.2009.00819.x
Web of Science ID:	000272867000026
URI:	https://boris.unibe.ch/id/eprint/38364 (FactScience: 221219)