Clostridium perfringens beta-toxin binding to vascular endothelial cells in a human case of enteritis necroticans

Miclard, J.; van Baarlen, J.; Wyder, M.; Grabscheid, B.; Posthaus, H. (2009). Clostridium perfringens beta-toxin binding to vascular endothelial cells in a human case of enteritis necroticans. Journal of medical microbiology, 58(Pt 6), pp. 826-8. Reading: SGM 10.1099/jmm.0.008060-0

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Clostridium perfringens type C-induced enteritis necroticans is a rare but often fatal disease in humans. A consistent histopathological finding is an acute, deep necrosis of the small intestinal mucosa associated with acute vascular necrosis and massive haemorrhage in the lamina propria and submucosa. Retrospective immunohistochemical investigations of tissues from a diabetic adult who died of enteritis necroticans revealed endothelial localization of C. perfringens beta-toxin in small intestinal lesions. Our results indicate that vascular necrosis might be induced by a direct interaction between C. perfringens beta-toxin and endothelial cells and that targeted disruption of endothelial cells plays a role in the pathogenesis of enteritis necroticans.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Miclard, Julien and Posthaus, Horst

ISSN:

0022-2615

Publisher:

SGM

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1099/jmm.0.008060-0

Web of Science ID:

000266615900018

URI:

https://boris.unibe.ch/id/eprint/38365 (FactScience: 221224)

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