Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: a randomised, double blind, placebo-controlled study

Willemse, T.; Bardagi, M.; Carlotti, D.N.; Ferrer, L.; Fondati, A.; Fontaine, J.; Leistra, M.; Noli, C.; Ordeix, L.; Scarampella, F.; Schleifer, S.; Sinke, J.; Roosje, P. (2009). Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: a randomised, double blind, placebo-controlled study. Veterinary journal, 180(3), pp. 337-42. Amsterdam: Elsevier 10.1016/j.tvjl.2008.01.004

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A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n=14) or a placebo (n=11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P>0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology

UniBE Contributor:

Roosje, Pieternella

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1016/j.tvjl.2008.01.004

Web of Science ID:

000264897700010

URI:

https://boris.unibe.ch/id/eprint/38397 (FactScience: 221310)

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