Tucker, Richard P.; Ferralli, Jacqueline; Schittny, Johannes C.; Chiquet-Ehrismann, Ruth (2013). Tenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation and migration. Journal of cell science, 126(22), pp. 5111-5115. Company of Biologists Limited 10.1242/jcs.134650
Full text not available from this repository.The whisker follicle has CD34-positive stem cells that migrate from their niche near the bulge along the glassy membrane to the whisker bulb, where they participate in the formation of the whisker shaft. Using immunohistochemistry we found the glycoprotein tenascin-C in the fibrous capsule of mouse whisker follicles, along the glassy membrane and in the trabecular region surrounding keratin-15-negative, CD34-positive stem cells. The related glycoprotein tenascin-W is found in the CD34-positive stem cell niche, in nearby trabeculae, and along the glassy membrane. Tenascin-W is also found in the neural stem cell niche of nearby hair follicles. The formation of stress fibers and focal adhesion complexes in CD34-positive whisker-derived stem cells cultured on fibronectin was inhibited by both tenascin-C and tenascin-W, which is consistent with a role for these glycoproteins in promoting the migration of these cells from the niche to the whisker bulb. Tenascin-C, but not tenascin-W, increased the proliferation of whisker follicle stem cells in vitro. Thus, the CD34-positive whisker follicle stem cell niche contains both tenascin-C and tenascin-W, and these glycoproteins may play a role in directing the migration and proliferation of these stem cells.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy |
UniBE Contributor: |
Schittny, Johannes |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0021-9533 |
Publisher: |
Company of Biologists Limited |
Language: |
English |
Submitter: |
Johannes Schittny |
Date Deposited: |
10 Apr 2014 11:06 |
Last Modified: |
05 Dec 2022 14:26 |
Publisher DOI: |
10.1242/jcs.134650 |
PubMed ID: |
24101721 |
URI: |
https://boris.unibe.ch/id/eprint/38869 |
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