Dose optimization approach to fast X-ray microtomography of the lung alveoli

Lovric, Goran; Barré, Sébastien F.; Schittny, Johannes C.; Roth-Kleiner, Matthias; Stampanoni, Marco; Mokso, Rajmund (2013). Dose optimization approach to fast X-ray microtomography of the lung alveoli. Journal of applied crystallography, 46(Pt. 4), pp. 856-860. Blackwell 10.1107/S0021889813005591

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A basic prerequisite for in vivo X-ray imaging of the lung is the exact determination of radiation dose. Achieving resolutions of the order of micrometres may become particularly challenging owing to increased dose, which in the worst case can be lethal for the imaged animal model. A framework for linking image quality to radiation dose in order to optimize experimental parameters with respect to dose reduction is presented. The approach may find application for current and future in vivo studies to facilitate proper experiment planning and radiation risk assessment on the one hand and exploit imaging capabilities on the other.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Barré, Sébastien and Schittny, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-8898

Publisher:

Blackwell

Language:

English

Submitter:

Johannes Schittny

Date Deposited:

10 Apr 2014 11:14

Last Modified:

10 Apr 2014 11:14

Publisher DOI:

10.1107/S0021889813005591

PubMed ID:

24046488

Uncontrolled Keywords:

X-ray microtomography, dose optimization, lung aveoli, radiation dose

URI:

https://boris.unibe.ch/id/eprint/38871

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