Everolimus dual effects of an area vasculosa angiogenesis and lymphangiogenesis

Ceausu, Raluca Amalia; Cimpean, Anca Maria; Dimova, Ivanka; Hlushchuk, Ruslan; Djonov, Valentin; Gaje, Pusa Nela; Raica, Marius (2013). Everolimus dual effects of an area vasculosa angiogenesis and lymphangiogenesis. In Vivo, 27(1), pp. 61-66. International Institute of Anticancer Research (IIAR)

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Recently approved as treatment for astrocytoma, kidney and pancreatic cancer, everolimus acts on tumor cells by inhibiting tumor cell growth and proliferation, as well as by inhibition of angiogenic activity by both direct effects on vascular cell proliferation and indirect effects on growth factor production. The effects of everolimus on early stages of normal vasculogenesis, angiogenesis and lymphangiogenesis are not yet available. We found increased development of intravascular pillars by using area vasculosa of the chick chorioallantoic membrane treated with everolimus. An active lymphangiogenic response was highlighted by the expression of Prospero homeobox protein 1 (Prox1) and podoplanin, together with vascular endothelial growth factor receptor C (Vegf-C) and vascular endothelial growth factor receptor 3 (Vegfr-3) expression on day 4 in the treated group. These findings suggest a potential role of everolimus in the activation of lymphangiogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Dimova, Ivanka; Hlushchuk, Ruslan and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0258-851X

Publisher:

International Institute of Anticancer Research (IIAR)

Language:

English

Submitter:

Beatrice Itten

Date Deposited:

04 Apr 2014 19:02

Last Modified:

16 Sep 2014 17:06

PubMed ID:

23239853

Web of Science ID:

000312745500007

URI:

https://boris.unibe.ch/id/eprint/39463

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