Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma

Karoubi, Golnaz; Cortes-Dericks, Lourdes; Gugger, Mathias; Galetta, Domenico; Spaggiari, Lorenzo; Schmid, Ralph A (2010). Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma. Journal of surgical oncology, 102(6), pp. 689-98. Hoboken, N.J.: Wiley-Blackwell 10.1002/jso.21665

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Lung cancer is one of the leading causes of cancer-related deaths in the world. Although the origin still remains to be resolved, a prevailing hypothesis implies the involvement of cancer stem cells (CSCs) responsible for tumor initiation, maintenance, and progression. Embryonic stem cell marker, OCT4, encoding the spliced variants OCT4A and OCT4B, has recently been shown to have a dual role; as a potential adult stem cell marker and as a CSC marker in germline and somatic tumors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Karoubi, Golnaz; Gugger, Mathias and Schmid, Ralph

ISSN:

0022-4790

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.1002/jso.21665

PubMed ID:

20721963

Web of Science ID:

000283758300026

URI:

https://boris.unibe.ch/id/eprint/395 (FactScience: 198172)

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