Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors?

Baur, Roland; Gertsch, Jürg; Sigel, Erwin (2013). Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors? PeerJ, 1, e149. PeerJ, Ltd 10.7717/peerj.149

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NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Baur, Roland; Gertsch, Jürg and Sigel, Erwin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2167-8359

Publisher:

PeerJ, Ltd

Language:

English

Submitter:

Erwin Sigel

Date Deposited:

17 Apr 2014 09:17

Last Modified:

23 Dec 2014 13:34

Publisher DOI:

10.7717/peerj.149

PubMed ID:

24058880

Uncontrolled Keywords:

GABAA receptors, Endocannabinoids, GABA, 2-AG, NA-glycine

BORIS DOI:

10.7892/boris.39561

URI:

https://boris.unibe.ch/id/eprint/39561

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