Brain electrical microstates in subjects with panic disorder

Galderisi, Silvano; Bucci, Paola; Mucci, Armida; Bernardo, Antonietta; König, Thomas; Maj, Mario (2001). Brain electrical microstates in subjects with panic disorder. Brain research bulletin, 54(4), pp. 427-435. Elsevier 10.1016/S0361-9230(01)00439-7

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Brain electrical microstates represent spatial configurations of scalp recorded brain electrical activity and are considered to be the basic elements of stepwise processing of information in the brain. In the present study, the hypothesis of a temporo-limbic dysfunction in panic disorder (PD) was tested by investigating the topographic descriptors of brain microstates, in particular the one corresponding to the Late Positive Complex (LPC), an event-related potential (ERP) component with generators in these regions. ERPs were recorded in PD patients and matched healthy subjects during a target detection task, in a central (CC) and a lateral condition (LC). In the CC, a leftward shift of the LPC microstate positive centroid was observed in the patients with PD versus the healthy control subjects. In the LC, the topographic descriptor of the first microstate showed a rightward shift, while those of both the second and the fourth microstate, corresponding to the LPC, revealed a leftward shift in the PD patients versus the healthy control subjects. These findings indicate an overactivation of the right hemisphere networks involved in early visual processing and a hypoactivation of the right hemisphere circuits involved in LPC generators in PD. In line with this interpretation, the abnormal topography of the LPC microstate, observed in the CC, was associated with a worse performance on a test exploring right temporo-hippocampal functioning. Topographical abnormalities found for the LPC microstate in the LC were associated with a higher number of panic attacks, suggesting a pathogenetic role of the right temporo-hippocampal dysfunction in PD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0361-9230

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

24 Jan 2014 08:53

Last Modified:

20 Dec 2014 09:07

Publisher DOI:

10.1016/S0361-9230(01)00439-7

Uncontrolled Keywords:

Event-related potentials; Late Positive Complex; Temporo-limbic networks; Right hemisphere

BORIS DOI:

10.7892/boris.39698

URI:

https://boris.unibe.ch/id/eprint/39698

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