A deviant EEG brain microstate in acute, neuroleptic-naive schizophrenics at rest

König, Thomas; Lehmann, Dietrich; Merlo, Marco C. G.; Kochi, Kieko; Hell, Daniel; Koukkou, Martha (1999). A deviant EEG brain microstate in acute, neuroleptic-naive schizophrenics at rest. European archives of psychiatry and clinical neuroscience, 249(4), pp. 205-211. Springer 10.1007/s004060050088

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Momentary brain electric field configurations are manifestations of momentary global functional states of the brain. Field configurations tend to persist over some time in the sub-second range (“microstates”) and concentrate within few classes of configurations. Accordingly, brain field data can be reduced efficiently into sequences of re-occurring classes of brain microstates, not overlapping in time. Different configurations must have been caused by different active neural ensembles, and thus different microstates assumedly implement different functions. The question arises whether the aberrant schizophrenic mentation is associated with specific changes in the repertory of microstates. Continuous sequences of brain electric field maps (multichannel EEG resting data) from 9 neuroleptic-naive, first-episode, acute schizophrenics and from 18 matched controls were analyzed. The map series were assigned to four individual microstate classes; these were tested for differences between groups. One microstate class displayed significantly different field configurations and shorter durations in patients than controls; degree of shortening correlated with severity of paranoid symptomatology. The three other microstate classes showed no group differences related to psychopathology. Schizophrenic thinking apparently is not a continuous bias in brain functions, but consists of intermittent occurrences of inappropriate brain microstates that open access to inadequate processing strategies and context information

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued]

UniBE Contributor:

König, Thomas; Merlo, Christoph Marco and Koukkou-Lehmann, Martha


600 Technology > 610 Medicine & health








Thomas König

Date Deposited:

14 Aug 2014 17:11

Last Modified:

28 Dec 2014 17:43

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Key words Attention, Working memory, Acute neuroleptic-naive schizophrenics, Brain electric microstates, Multichannel EEG





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