Space–oriented EEG segmentation reveals changes in brain electric–field maps under the influence of a nootropic drug

Lehmann, Dietrich; Wackermann, Jiri; Michel, Christoph M.; Koenig, Thomas (1993). Space–oriented EEG segmentation reveals changes in brain electric–field maps under the influence of a nootropic drug. Psychiatry research: Neuroimaging, 50(4), pp. 275-282. Elsevier 10.1016/0925-4927(93)90005-3

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Map landscape-based segmentation of the sequences of momentary potential distribution maps (42-channel recordings) into brain microstates during spontaneous brain activity was used to study brain electric field spatial effects of single doses of piracetam (2.9, 4.8, and 9.6 g Nootropil® UCB and placebo) in a double-blind study of five normal young volunteers. Four 15-second epochs were analyzed from each subject and drug condition. The most prominent class of microstates (covering 49% of the time) consisted of potential maps with a generally anterior-posterior field orientation. The map orientation of this microstate class showed an increasing clockwise deviation from the placebo condition with increasing drug doses (Fisher's probability product, p < 0.014). The results of this study suggest the use of microstate segmentation analysis for the assessment of central effects of medication in spontaneous multichannel electroencephalographic data, as a complementary approach to frequency-domain analysis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

18 Aug 2014 15:13

Last Modified:

22 Aug 2014 11:34

Publisher DOI:

10.1016/0925-4927(93)90005-3

PubMed ID:

8177925

Uncontrolled Keywords:

electroencephalography, brain electric microstates, cognitionenhancing drugs, piracetam

URI:

https://boris.unibe.ch/id/eprint/39740

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