Frequency-domain source localization shows state-dependent diazepam effects in 47-channel EEG

Michel, C. M.; Pascual Marqui, R. D.; Strik, W. K.; König, T.; Lehmann, D. (1995). Frequency-domain source localization shows state-dependent diazepam effects in 47-channel EEG. Journal of neural transmission, 99(1-3), pp. 157-171. Springer 10.1007/BF01271476

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The topic of this study was to evaluate state-dependent effects of diazepam on the frequency characteristics of 47-channel spontaneous EEG maps. A novel method, the FFT-Dipole-Approximation (Lehmann and Michel, 1990), was used to study effects on the strength and the topography of the maps in the different frequency bands. Map topography was characterized by the 3-dimensional location of the equivalent dipole source and map strength was defined as the spatial standard deviation (the Global Field Power) of the maps of each frequency point. The Global Field Power can be considered as a measure of the amount of energy produced by the system, while the source location gives an estimate of the center of gravity of all sources in the brain that were active at a certain frequency. State-dependency was studied by evaluating the drug effects before and after a continuous performance task of 25 min duration. Clear interactions between drug (diazepam vs. placebo) and time after drug intake (before and after the task) were found, especially in the inferior-superior location of the dipole sources. It supports the hypothesis that diazepam, like other drugs, has different effects on brain functions depending on the momentary functional state of the brain. In addition to the drug effects, clearly different source locations and Global Field Power were found for the different frequency bands, replicating earlier reports (Michel et al., 1992).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Strik, Werner and König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0300-9564

Publisher:

Springer

Language:

English

Submitter:

Thomas König

Date Deposited:

18 Aug 2014 16:08

Last Modified:

08 Nov 2016 12:42

Publisher DOI:

10.1007/BF01271476

PubMed ID:

8579802

Uncontrolled Keywords:

Pharmaco-EEG, EEG mapping, FFT-dipole-Approximation, frequency domain EEG sources, diazepam, state dependency, reactivity

URI:

https://boris.unibe.ch/id/eprint/39743

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