Hemispheric lateralization patterns and psychotic experiences in healthy subjects

Mucci, Armida; Galderisi, Silvana; Bucci, Paola; Tresca, E.; Forte, A.; Koenig, Thomas; Maj, Mario (2005). Hemispheric lateralization patterns and psychotic experiences in healthy subjects. Psychiatry research: Neuroimaging, 139(2), pp. 141-154. Elsevier 10.1016/j.pscychresns.2004.03.006

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The hypothesis that psychotic experiences in healthy subjects are associated with a dysfunction of the right hemisphere is supported by some, but not all, available studies. Differences in gender composition of study samples may explain in part the divergent findings. The present study was carried out in 42 healthy, right-handed university students. Scores on the Schizophrenia and Paranoia scales of the Minnesota Multidimensional Personality Inventory-2 were used in correlation analyses and to define a High- and a Low-Psychotic group. Brain Electrical Microstates and Low Resolution Electromagnetic Tomography (LORETA) source analyses of the auditory P300 (P3a and P3b) components of the event-related potential, as well as a battery of neuropsychological tests, were used to assess hemispheric functioning. Scores on the Paranoia scale were positively associated with a leftward shift of the P3a topographic descriptors in females but not in males. When comparing High-Psychotic and Low-Psychotic females, a leftward shift of P3a descriptors and an increased cortical activation in left fronto-temporal areas were observed in the High-Psychotic group. Our results demonstrated gender-related differences in the pattern of hemispheric imbalance associated with psychotic experiences in healthy subjects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

18 Aug 2014 16:32

Last Modified:

12 Jan 2015 10:21

Publisher DOI:

10.1016/j.pscychresns.2004.03.006

PubMed ID:

15961295

Uncontrolled Keywords:

Event-related potentials, LORETA source imaging, Brain electrical microstates, Cognitive integration, Gender

BORIS DOI:

10.7892/boris.39746

URI:

https://boris.unibe.ch/id/eprint/39746

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