EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer's disease

Nishida, Keiichiro; Morishima, Yosuke; Yoshimura, Masafumi; Isotani, Toshiaki; Irisawa, Satoshi; Jann, Kay; Dierks, Thomas; Strik, Werner; Kinoshita, Toshihiko; Koenig, Thomas (2013). EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer's disease. Clinical neurophysiology, 124(6), pp. 1106-1114. Elsevier 10.1016/j.clinph.2013.01.005

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OBJECTIVE: There are relevant links between resting-state fMRI networks, EEG microstate classes and psychopathological alterations in mental disorders associated with frontal lobe dysfunction. We hypothesized that a certain microstate class, labeled C and correlated with the salience network, was impaired early in frontotemporal dementia (FTD), and that microstate class D, correlated with the frontoparietal network, was impaired in schizophrenia. METHODS: We measured resting EEG microstate parameters in patients with mild FTD (n = 18), schizophrenia (n = 20), mild Alzheimer's disease (AD; n = 19) and age-matched controls (old n = 19, young n = 18) to investigate neuronal dynamics at the whole-brain level. RESULTS: The duration of class C was significantly shorter in FTD than in controls and AD, and the duration of class D was significantly shorter in schizophrenia than in controls, FTD and AD. Transition analysis showed a reversed sequence of activation of classes C and D in FTD and schizophrenia patients compared with that in controls, with controls preferring transitions from C to D, and patients preferring D to C. CONCLUSION: The duration and sequence of EEG microstates reflect specific aberrations of frontal lobe functions in FTD and schizophrenia. SIGNIFICANCE: This study highlights the importance of subsecond brain dynamics for understanding of psychiatric disorders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Nishida, Keiichiro; Morishima, Yosuke; Jann, Kay; Dierks, Thomas; Strik, Werner and König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

17 Apr 2014 09:25

Last Modified:

13 Jul 2015 15:24

Publisher DOI:

10.1016/j.clinph.2013.01.005

PubMed ID:

23403263

Uncontrolled Keywords:

EEG, EEG microstates, Salience network, Frontoparietal network, Frontotemporal dementia, Schizophrenia, Resting state

URI:

https://boris.unibe.ch/id/eprint/39748

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