Global, regional, and local measures of complexity of multichannel electroencephalography in acute, neuroleptic-naive, first-break schizophrenics

Saito, Naomi; Kuginuki, Toshiaki; Yagyu, Takami; Kinoshita, Toshihiko; Koenig, Thomas; Pascual-Marqui, Roberto D.; Kochi, Kieko; Wackermann, Jiri; Lehmann, Dietrich (1998). Global, regional, and local measures of complexity of multichannel electroencephalography in acute, neuroleptic-naive, first-break schizophrenics. Biological psychiatry, 43(11), pp. 794-802. Elsevier 10.1016/S0006-3223(97)00547-7

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Background: Schizophrenic symptoms commonly are felt to indicate a loosened coordination, i.e. a decreased connectivity of brain processes. Methods: To address this hypothesis directly, global and regional multichannel electroencephalographic (EEG) complexities (omega complexity and dimensional complexity) and single channel EEG dimensional complexities were calculated from 19-channel EEG data from 9 neuroleptic-naive, first-break, acute schizophrenics and 9 age- and sex-matched controls. Twenty artifact-free 2 second EEG epochs during resting with closed eyes were analyzed (2–30 Hz bandpass, average reference for global and regional complexities, local EEG gradient time series for single channels). Results: Anterior regional Omega-Complexity was significantly increased in schizophrenics compared with controls (p < 0.001) and anterior regional Dimensional Complexity showed a trend for increase. Single channel Dimensional Complexity of local gradient waveshapes was prominently increased in the schizophrenics at the right precentral location (p = 0.003). Conclusions: The results indicate a loosened cooperativity or coordination (vice versa: an increased independence) of the active brain processes in the anterior brain regions of the schizophrenics.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-3223

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

18 Aug 2014 08:42

Last Modified:

02 Jan 2015 07:07

Publisher DOI:

10.1016/S0006-3223(97)00547-7

PubMed ID:

9611668

Uncontrolled Keywords:

global/regional omega complexity, global/regional dimensional complexity, correlation dimension, electroencephalographic gradients, multichannel electroencephalography, acute neuroleptic-naive schizophrenics

BORIS DOI:

10.7892/boris.39760

URI:

https://boris.unibe.ch/id/eprint/39760

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