Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations

Strelets, V.; Faber, P. L.; Golikova, J.; Novototsky-Vlasov, V.; Koenig, Thomas; Gianotti, Lorena; Gruzelier, J. H.; Lehmann, D. (2003). Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations. Clinical neurophysiology, 114(11), pp. 2043-2051. Elsevier 10.1016/s1388-2457(03)00211-6

[img] Text
Moscow Schizo.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (171kB) | Request a copy

OBJECTIVE: In young, first-episode, never-treated schizophrenics compared with controls, (a) generally shorter durations of EEG microstates were reported (Koukkou et al., Brain Topogr 6 (1994) 251; Kinoshita et al., Psychiatry Res Neuroimaging 83 (1998) 58), and (b) specifically, shorter duration of a particular class of microstates (Koenig et al., Eur Arch Psychiatry Clin Neurosci 249 (1999) 205). We now examined whether older, chronic schizophrenic patients with positive symptomatology also show these characteristics. METHODS: Multichannel resting EEG (62.2 s/subject) from two subject groups, 14 patients (36.1+/-10.2 years old) and 13 controls (35.1+/-8.2 years old), all males, was analyzed into microstates using a global approach for microstate analysis that clustered the microstates into 4 classes (Koenig et al., 1999). RESULTS: (a) Hypothesis testing of general microstate shortening supported a trend (P=0.064). (b) Two-way repeated measure ANOVA (two subject groupsx4 microstate classes) showed a significant group effect for microstate duration. Posthoc tests revealed that a microstate class with brain electric field orientation from left central to right central-posterior had significantly shorter microstates in patients than controls (68.5 vs. 76.1 ms, P=0.034). CONCLUSIONS: The results were in line with the results from young, never-treated, productive patients, thus suggesting that in schizophrenic information processing, one class of mental operations might intermittently cause deviant mental constructs because of premature termination of processing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
07 Faculty of Human Sciences > Institute of Psychology > Social Psychology and Social Neuroscience

UniBE Contributor:

König, Thomas and Gianotti, Lorena

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

20 Aug 2014 09:45

Last Modified:

28 Dec 2014 11:21

Publisher DOI:

10.1016/s1388-2457(03)00211-6

PubMed ID:

14580602

BORIS DOI:

10.7892/boris.39767

URI:

https://boris.unibe.ch/id/eprint/39767

Actions (login required)

Edit item Edit item
Provide Feedback