Cell death in immune thrombocytopenia: novel insights and perspectives

von Gunten, Stephan; Wehrli, Marc; Simon, Hans-Uwe (2013). Cell death in immune thrombocytopenia: novel insights and perspectives. Seminars in hematology, 1(50), pp. 109-115. W.B. Saunders 10.1053/j.seminhematol.2013.03.016

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Immune thrombocytopenia (ITP) is a complex disease. The pathogenic and clinical heterogeneity of ITP is reflected by reports on variability in patient history and treatment response, in concert with recent evidence from mechanistic studies. Programmed cell death (PCD) pathways are thought to play a peculiar role in the megakaryocyte lineage in terms of hemostasis and the generation and function of megakaryocytes and platelets; unbalanced genetic or environmental disturbances of these tightly regulated pathways may cause thrombocytopenia. Dysregulated PCD has also been linked to peripheral platelet destruction, intramedullary apoptosis, and inefficient thrombopoiesis in ITP. In this article, we discuss novel and controversial findings on the role of PCD in the megakaryocyte lineage and their potential implications in terms of pathogenesis, diagnosis, and treatment of ITP.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

von Gunten, Stephan; Wehrli, Marc and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0037-1963

Publisher:

W.B. Saunders

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Anita Dähler

Date Deposited:

16 Dec 2013 10:40

Last Modified:

01 Apr 2019 09:29

Publisher DOI:

10.1053/j.seminhematol.2013.03.016

PubMed ID:

23664507

BORIS DOI:

10.7892/boris.39777

URI:

https://boris.unibe.ch/id/eprint/39777

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