Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials

Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European journal of orthodontics, 35(6), pp. 783-789. Oxford University Press 10.1093/ejo/cjs108

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SUMMARY Split-mouth designs first appeared in dental clinical trials in the late sixties. The main advantage of this study design is its efficiency in terms of sample size as the patients act as their own controls. Cited disadvantages relate to carry-across effects, contamination or spilling of the effects of one intervention to another, period effects if the interventions are delivered at different time periods, difficulty in finding similar comparison sites within patients and the requirement for more complex data analysis. Although some additional thought is required when utilizing a split-mouth design, the efficiency of this design is attractive, particularly in orthodontic clinical studies where carry-across, period effects and dissimilarity between intervention sites does not pose a problem. Selection of the appropriate research design, intervention protocol and statistical method accounting for both the reduced variability and potential clustering effects within patients should be considered for the trial results to be valid.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Pandis, Nikolaos; Katsaros, Christos and Eliades, Theodore

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0141-5387

Publisher:

Oxford University Press

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

24 Jan 2014 13:53

Last Modified:

27 Apr 2018 08:34

Publisher DOI:

10.1093/ejo/cjs108

PubMed ID:

23376899

BORIS DOI:

10.7892/boris.39984

URI:

https://boris.unibe.ch/id/eprint/39984

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