Cluster randomized clinical trials in orthodontics: design, analysis and reporting issues

Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Eliades, Theodore (2013). Cluster randomized clinical trials in orthodontics: design, analysis and reporting issues. European journal of orthodontics, 35(5), pp. 669-75. Oxford University Press 10.1093/ejo/cjs072

[img] Text
669.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy
[img]
Preview
Text
cjs072.pdf - Other
Available under License Publisher holds Copyright.

Download (1MB) | Preview

Cluster randomized trials (CRTs) use as the unit of randomization clusters, which are usually defined as a collection of individuals sharing some common characteristics. Common examples of clusters include entire dental practices, hospitals, schools, school classes, villages, and towns. Additionally, several measurements (repeated measurements) taken on the same individual at different time points are also considered to be clusters. In dentistry, CRTs are applicable as patients may be treated as clusters containing several individual teeth. CRTs require certain methodological procedures during sample calculation, randomization, data analysis, and reporting, which are often ignored in dental research publications. In general, due to similarity of the observations within clusters, each individual within a cluster provides less information compared with an individual in a non-clustered trial. Therefore, clustered designs require larger sample sizes compared with non-clustered randomized designs, and special statistical analyses that account for the fact that observations within clusters are correlated. It is the purpose of this article to highlight with relevant examples the important methodological characteristics of cluster randomized designs as they may be applied in orthodontics and to explain the problems that may arise if clustered observations are erroneously treated and analysed as independent (non-clustered).

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Pandis, Nikolaos and Eliades, Theodore

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0141-5387

Publisher:

Oxford University Press

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

28 Jan 2014 08:27

Last Modified:

27 Apr 2018 10:00

Publisher DOI:

10.1093/ejo/cjs072

PubMed ID:

23041934

BORIS DOI:

10.7892/boris.40062

URI:

https://boris.unibe.ch/id/eprint/40062

Actions (login required)

Edit item Edit item
Provide Feedback