Tooth eruption: altered gene expression in the dental follicle of patients with cleidocranial dysplasia

Dorotheou, D; Gkantidis, Nikolaos; Karamolegkou, M; Kalyvas, D; Kiliaridis, S; Kitraki, E (2013). Tooth eruption: altered gene expression in the dental follicle of patients with cleidocranial dysplasia. Orthodontics & Craniofacial Research, 16(1), pp. 20-7. Wiley 10.1111/ocr.12000

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OBJECTIVES The dental follicle plays an important role in tooth eruption by providing key regulators of osteogenesis and bone resorption. Patients with cleidocranial dysplasia (CCD) exhibit delayed tooth eruption in combination with increased bone density in the maxilla and mandible, suggesting disturbances in bone remodeling. The aim of this study was to determine the expression of genes relevant for tooth eruption and bone remodeling in the dental follicles of patients with CCD and normal subjects. MATERIAL AND METHODS Thirteen dental follicles were isolated from five unrelated patients with CCD, and fourteen dental follicles were obtained from 10 healthy individuals. All teeth were in the intraosseous phase of eruption. The expression of RANK, RANKL, OPG, and CSF-1 was determined by quantitative RT-PCR. RESULTS In patients with CCD, the mRNA levels of RANK, OPG, and CSF-1 were significantly elevated compared with the control group. Accordingly, the ratios of RANKL/OPG and RANKL/RANK mRNAs were significantly decreased in patients with CCD. CONCLUSION The observed alterations in the expression and ratios of the aforementioned factors in the dental follicle of CCD individuals suggest a disturbed paracrine signaling for bone remodeling that could be responsible for the impaired tooth eruption seen in these patients.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Gkantidis, Nikolaos


600 Technology > 610 Medicine & health


1601-6335, 1601-6343






Eveline Carmen Schuler

Date Deposited:

18 Feb 2014 10:43

Last Modified:

25 Jan 2017 12:15

Publisher DOI:


PubMed ID:



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