Clinical and pathological analysis of epidural inflammation in intervertebral disk extrusion in dogs

Fadda, A.; Oevermann, A.; Vandevelde, M.; Doherr, Marcus; Forterre, F.; Henke, D. (2013). Clinical and pathological analysis of epidural inflammation in intervertebral disk extrusion in dogs. Journal of veterinary internal medicine, 27(4), pp. 924-934. Wiley-Blackwell 10.1111/jvim.12095

Text jvim12095.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (720kB)

BACKGROUND

Little is known about the pathologic changes in the epidural space after intervertebral disk (IVD) extrusion in the dog.

OBJECTIVES

To analyze the pathology of the epidural inflammatory response, and to search for correlations between this process and clinical findings.

METHODS

Clinical data from 105 chondrodystrophic (CD) and nonchondrodystrophic (NCD) dogs with IVD extrusion were recorded. Epidural material from these dogs was examined histopathologically and immunohistochemically. Using statistical analysis, we searched for correlations between severity of epidural inflammation and various clinical and pathologic variables.

RESULTS

Most dogs exhibited an epidural inflammatory response, ranging from acute invasion of neutrophils to formation of chronic granulation tissue. The mononuclear inflammatory infiltrates consisted mostly of monocytes and macrophages and only few T and B cells. Surprisingly, chronic inflammatory patterns also were found in animals with an acute clinical history. Severity of the epidural inflammation correlated with degree of the epidural hemorrhage and nucleus pulposus calcification (P = .003 and .040), but not with age, chondrodystrophic phenotype, neurologic grade, back pain, pretreatment, or duration. The degree of inflammation was statistically (P = .021) inversely correlated with the ability to regain ambulation.

CONCLUSION AND CLINICAL IMPORTANCE

Epidural inflammation occurs in the majority of dogs with IVD extrusion and may develop long before the onset of clinical signs. Presence of calcified IVD material and hemorrhage in the epidural space may be the triggers of this lesion rather than an adaptive immune response to the nucleus pulposus as suggested in previous studies. Because epidural inflammation may affect outcome, further research is warranted.

Interest & Impact

Downloads

0 since deposited on 05 Mar 2014
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item