Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout

Burki, Richard; Krasnov, A.; Bettge, Kathrin; Rexroad, C. E.; Afanasyev, S.; Antikainen, M.; Burkhardt-Holm, P.; Wahli, Thomas; Segner, Helmut (2012). Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout. Environmental toxicology and chemistry, 31(10), pp. 2318-23. SETAC Press 10.1002/etc.1966

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To examine the behavior of the estrogenic biomarker vitellogenin (VTG) under the combined impact of estrogens and pathogens, parasite-infected or noninfected rainbow trout were exposed to two doses of 17beta-estradiol (E2). Infected and E2-exposed fish showed significantly lower hepatic VTG mRNA levels than healthy fish. Transcriptome data suggest that this was due to energetic constraints. Reduced responsiveness of the VTG biomarker in parasitized fish might obscure detection of low-level field exposure.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Burki, Richard; Bettge, Kathrin; Wahli, Thomas and Segner, Helmut

Subjects:

600 Technology > 630 Agriculture

ISSN:

0730-7268

Publisher:

SETAC Press

Language:

English

Submitter:

Andrea Stettler

Date Deposited:

27 Jan 2014 10:43

Last Modified:

31 Mar 2016 09:17

Publisher DOI:

10.1002/etc.1966

PubMed ID:

22847860

BORIS DOI:

10.7892/boris.40437

URI:

https://boris.unibe.ch/id/eprint/40437

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