Absorbable collagen membranes for periodontal regeneration: a systematic review

Stoecklin-Wasmer, C; Rutjes, A W S; Da Costa, B R; Salvi, Giovanni; Jüni, P; Sculean, Anton (2013). Absorbable collagen membranes for periodontal regeneration: a systematic review. Journal of dental research, 92(9), pp. 773-81. Sage 10.1177/0022034513496428

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Guided tissue regeneration (GTR) with bioabsorbable collagen membranes (CM) is commonly used for the treatment of periodontal defects. The objective of this systematic review of randomized clinical trials was to assess the clinical efficacy of GTR procedures with CM, with or without bone substitutes, in periodontal infrabony defects compared with that of open flap debridement (OFD) alone. Primary outcomes were tooth loss and gain in clinical attachment level (CAL). Screening of records, data extraction, and risk-of-bias assessments were performed by two reviewers. Weighted mean differences were estimated by random effects meta-analysis. We included 21 reports on 17 trials. Risk of bias was generally high. No data were available for the primary outcome tooth loss. The summary treatment effect for change in CAL for GTR with CM compared with OFD was 1.58 mm (95% CI, 1.27 to 1.88). Despite large between-trial heterogeneity (I2 = 75%, p < .001), all trials favored GTR over OFD. No differences in treatment effects were detected between trials of GTR with CM alone and trials of GTR with CM in combination with bone substitutes (p for interaction, .31). GTR with CM, with or without substitutes, may result in improved clinical outcomes compared with those achieved with OFD alone. Our findings support GTR with CM for the treatment of infrabony periodontal defects.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Stöcklin, Christin; Rutjes, Anne; Da Costa, Bruno; Salvi, Giovanni; Jüni, Peter and Sculean, Anton


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Eveline Carmen Schuler

Date Deposited:

04 Feb 2014 17:33

Last Modified:

25 Jan 2017 12:15

Publisher DOI:


PubMed ID:


Additional Information:

Stoecklin and Rutjes contributed equally to this work.

Uncontrolled Keywords:

biomaterial(s), clinical studies/trials, guided tissue regeneration, meta-analysis, periodontal disease(s), periodontitis, surgery





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