Stadelmann, Pascale; Alessandri, Regina; Eick, Sigrun; Salvi, Giovanni E.; Surbek, Daniel; Sculean, Anton (2013). The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review. Clinical oral investigations, 17(6), pp. 1453-1463. Springer-Verlag 10.1007/s00784-013-0952-0
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OBJECTIVES
The association between periodontal disease and adverse pregnancy outcomes (APO), primarily preterm birth (PTB), is still controversially discussed in the literature. Therefore, the aim of the present systematic review was to analyze the existing literature on the potential association between inflammatory mediators detected in gingival crevicular fluid (GCF) and APO.
MATERIALS AND METHODS
MEDLINE (PubMed) and EMBASE databases were searched for entries up to April 2012 and studies were selected by two independent reviewers.
RESULTS
The majority of the eight studies included confirmed a positive association between GCF mediators, such as interleukin-1β, prostaglandin E2, and tumor necrosis factor-alpha, and APO. Due to the heterogeneity and variability of the available studies, no meta-analysis could be performed.
CONCLUSIONS
A positive association between GCF inflammatory mediator levels and APO/PTB might be present but the results need to be considered with great caution because of the heterogeneity and variability among the studies. Further studies with an adequate number of patients allowing for an appropriate analysis are warranted to definitely confirm this association.
CLINICAL RELEVANCE
The present findings suggest that an association between GCF inflammatory mediator levels and APO might exist.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Stadelmann, Pascale, Alessandri, Regina, Eick, Sigrun, Salvi, Giovanni Edoardo, Surbek, Daniel, Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
25 Feb 2014 10:11 |
Last Modified: |
05 Dec 2022 14:27 |
Publisher DOI: |
10.1007/s00784-013-0952-0 |
PubMed ID: |
23468255 |
BORIS DOI: |
10.7892/boris.40635 |
URI: |
https://boris.unibe.ch/id/eprint/40635 |
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