Role of amylase, mucin, IgA and albumin on salivary protein buffering capacity: a pilot study

Cheaib, Zeinab; Lussi, Adrian (2013). Role of amylase, mucin, IgA and albumin on salivary protein buffering capacity: a pilot study. Journal of biosciences, 38(2), pp. 259-265. Indian Academy of Sciences 10.1007/s12038-013-9311-1

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It has been suggested that proteins serve as major salivary buffers below pH5. It remains unclear, however, which salivary proteins are responsible for these buffering properties. The aim of this pilot study was to evaluate the correlation between salivary concentration of total protein, amylase, mucin, immunoglobulin A (IgA), albumin and total salivary protein buffering capacity at a pH range of 4-5. In addition, the buffering capacity and the number of carboxylic acid moieties of single proteins were assessed. Stimulated saliva samples were collected at 9:00, 13:00 and 17:00 from 4 healthy volunteers on 3 successive days. The buffering capacities were measured for total salivary protein or for specific proteins. Also, the concentration of total protein, amylase, mucin, IgA and albumin were analysed. Within the limits of the current study, it was found that salivary protein buffering capacity was highly positively correlated with total protein, amylase and IgA concentrations. A weak correlation was observed for both albumin and mucin individually. Furthermore, the results suggest that amylase contributed to 35 percent of the salivary protein buffering capacity in the pH range of 4-5.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Cheaib, Zeinab and Lussi, Adrian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0250-5991

Publisher:

Indian Academy of Sciences

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

25 Feb 2014 10:17

Last Modified:

29 Aug 2018 16:04

Publisher DOI:

10.1007/s12038-013-9311-1

PubMed ID:

23660660

BORIS DOI:

10.7892/boris.40801

URI:

https://boris.unibe.ch/id/eprint/40801

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