Impact of stent overlap on long-term clinical outcomes in patients treated with newer-generation drug-eluting stents

O'Sullivan, Crochan John; Stefanini, Giulio; Räber, Lorenz; Heg, Dik; Taniwaki, Masanori; Kalesan, Bindu; Pilgrim, Thomas; Zanchin, Thomas; Moschovitis, Aris; Büllesfeld, Lutz; Khattab, Ahmed Aziz; Meier, Bernhard; Wenaweser, Peter Martin; Jüni, Peter; Windecker, Stephan (2014). Impact of stent overlap on long-term clinical outcomes in patients treated with newer-generation drug-eluting stents. EuroIntervention, 9(9), pp. 1076-1084. Europa Digital & Publishing 10.4244/EIJV9I9A182

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Aims: Early-generation drug-eluting stent (DES) overlap (OL) is associated with impaired long-term clinical outcomes whereas the impact of OL with newer-generation DES is unknown. Our aim was to assess the impact of OL on long-term clinical outcomes among patients treated with newer-generation DES. Methods and results: We analysed the three-year clinical outcomes of 3,133 patients included in a prospective DES registry according to stent type (sirolimus-eluting stents [SES; N=1,532] versus everolimus-eluting stents [EES; N=1,601]), and the presence or absence of OL. The primary outcome was a composite of death, myocardial infarction (MI), and target vessel revascularisation (TVR). The primary endpoint was more common in patients with OL (25.1%) than in those with multiple DES without OL (20.8%, adj HR=1.46, 95% CI: 1.03-2.09) and patients with a single DES (18.8%, adj HR=1.74, 95% CI: 1.34-2.25, p<0.001) at three years. A stratified analysis by stent type showed a higher risk of the primary outcome in SES with OL (28.7%) compared to other SES groups (without OL: 22.6%, p=0.04; single DES: 17.6%, p<0.001), but not between EES with OL (22.3%) and other EES groups (without OL: 18.5%, p=0.30; single DES: 20.4%, p=0.20). Conclusions: DES overlap is associated with impaired clinical outcomes during long-term follow-up. Compared with SES, EES provide similar clinical outcomes irrespective of DES overlap status.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

O'Sullivan, Crochan John, Stefanini, Giulio, Räber, Lorenz, Heg, Dierik Hans, Taniwaki, Masanori, Kalesan, Bindu, Pilgrim, Thomas, Moschovitis, Aris, Büllesfeld, Lutz, Khattab, Ahmed Aziz, Meier, Bernhard, Wenaweser, Peter Martin, Jüni, Peter, Windecker, Stephan


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services




Europa Digital & Publishing




Doris Kopp Heim

Date Deposited:

19 Feb 2014 15:22

Last Modified:

05 Dec 2022 14:27

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