Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner

Schoepfer, Alain M.; Safroneeva, Ekaterina; Bussmann, Christian; Kuchen, Tanja; Portmann, Susanne; Simon, Hans-Uwe; Straumann, Alex (2013). Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology, 145(6), 1230-1236.e2. Elsevier 10.1053/j.gastro.2013.08.015

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BACKGROUND & AIMS Development of strictures is a major concern for patients with eosinophilic esophagitis (EoE). At diagnosis, EoE can present with an inflammatory phenotype (characterized by whitish exudates, furrows, and edema), a stricturing phenotype (characterized by rings and stenosis), or a combination of these. Little is known about progression of stricture formation; we evaluated stricture development over time in the absence of treatment and investigated risk factors for stricture formation. METHODS We performed a retrospective study using the Swiss EoE Database, collecting data on 200 patients with symptomatic EoE (153 men; mean age at diagnosis, 39 ± 15 years old). Stricture severity was graded based on the degree of difficulty associated with passing of the standard adult endoscope. RESULTS The median delay in diagnosis of EoE was 6 years (interquartile range, 2-12 years). With increasing duration of delay in diagnosis, the prevalence of fibrotic features of EoE, based on endoscopy, increased from 46.5% (diagnostic delay, 0-2 years) to 87.5% (diagnostic delay, >20 years; P = .020). Similarly, the prevalence of esophageal strictures increased with duration of diagnostic delay, from 17.2% (diagnostic delay, 0-2 years) to 70.8% (diagnostic delay, >20 years; P < .001). Diagnostic delay was the only risk factor for strictures at the time of EoE diagnosis (odds ratio = 1.08; 95% confidence interval: 1.040-1.122; P < .001). CONCLUSIONS The prevalence of esophageal strictures correlates with the duration of untreated disease. These findings indicate the need to minimize delay in diagnosis of EoE.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Safroneeva, Ekaterina and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

21 Feb 2014 12:16

Last Modified:

10 Sep 2017 12:36

Publisher DOI:

10.1053/j.gastro.2013.08.015

PubMed ID:

23954315

Additional Information:

Schoepfer and Safroneeva contributed equally to this work.

Uncontrolled Keywords:

Esophagus, Complications, Inflammation, Remodeling

BORIS DOI:

10.7892/boris.41337

URI:

https://boris.unibe.ch/id/eprint/41337

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