Future treatment strategies in ST-segment elevation myocardial infarction

Windecker, Stephan; Bax, Jeroen J.; Myat, Aung; Stone, Gregg W.; Marber, Michael S. (2013). Future treatment strategies in ST-segment elevation myocardial infarction. Lancet, 382(9892), pp. 644-657. Elsevier 10.1016/S0140-6736(13)61452-X

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Over the past five decades, management of acute ST-segment elevation myocardial infarction (STEMI) has evolved substantially. Current treatment encompasses a systematic chain of network activation, antithrombotic drugs, and rapid instigation of mechanical reperfusion, although pharmacoinvasive strategies remain relevant. Secondary prevention with drugs and lifestyle modifications completes the contemporary management package. Despite a tangible improvement in outcomes, STEMI remains a frequent cause of morbidity and mortality, justifying the quest to find new therapeutic avenues. Ways to reduce delays in doing coronary angioplasty after STEMI onset include early recognition of symptoms by patients and prehospital diagnosis by paramedics so that the emergency room can be bypassed in favour of direct admission to the catheterisation laboratory. Mechanical reperfusion can be optimised by improvements to stent design, whereas visualisation of infarct size has been improved by developments in cardiac MRI. Novel treatments to modulate the inflammatory component of atherosclerosis and the vulnerable plaque include use of bioresorbable vascular scaffolds and anti-proliferative drugs. Translational efforts to improve patients' outcomes after STEMI in relation to cardioprotection, cardiac remodelling, and regeneration are also being realised. This is the third in a Series of three papers about ST-segment elevation myocardial infarction.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0140-6736

Publisher:

Elsevier

Language:

English

Submitter:

Judith Liniger

Date Deposited:

24 Mar 2014 07:56

Last Modified:

28 Oct 2015 11:47

Publisher DOI:

10.1016/S0140-6736(13)61452-X

PubMed ID:

23953388

BORIS DOI:

10.7892/boris.41661

URI:

https://boris.unibe.ch/id/eprint/41661

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