Future perspectives in transcatheter aortic valve implantation

Bourantas, Christos V.; van Mieghem, Nicolas M.; Farooq, Vasim; Soliman, Osama I.; Windecker, Stephan; Piazza, Nicolo; Serruys, Patrick W. (2013). Future perspectives in transcatheter aortic valve implantation. International journal of cardiology, 168(1), pp. 11-18. Elsevier 10.1016/j.ijcard.2013.03.065

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Transcatheter aortic valve replacement (TAVR) constitutes a relatively new treatment option for the patients with severe symptomatic aortic stenosis. Evidence from registries and randomized control trials has underscored the value of this treatment in inoperable and high risk populations, while new developments in valve technology and TAVR enabling devices have reduced the risk of complications, simplified the procedure, and broadened the applications of this therapy. The initial promising clinical results and the potential of an effective less invasive treatment of aortic stenosis has not only created high expectations but also the need to address the pitfalls of TAVR technology. The evolving knowledge concerning the groups of patients who would benefit from this treatment, the limited long term follow-up data, the concerns about devices' long term durability, and the severity of complications remain important caveats which restrict the widespread clinical adoption of TAVR. The aim of this review article is to present the recent advances, highlight the limitations of TAVR technology, and discuss the future perspectives in this rapidly evolving field.

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