Pandey, Amit Vikram; Singh, N.; Tekwani, B. L.; Puri, S. K.; Chauhan, V. S. (1999). Assay of β-hematin formation by malaria parasite. Journal of pharmaceutical and biomedical analysis, 20(1-2), pp. 203-207. Pergamon Press 10.1016/S0731-7085(99)00021-7
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Novel leads are urgently required for designing antimalarials due to the reduced efficacy of presently available drugs. The malaria parasite has a unique reaction of heme polymerization, which has attracted much attention in the recent past as a target for the design of antimalarial drugs. The process is hampered by non-availability of a proper assay method. Currently available methods are cumbersome and require advanced instrumentation or radioactive substrates. Here, we are describing an assay for hemozoin formation that is simple and reproducible. This assay has routinely been used by us for the identification of potential compounds with antimalarial activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Endocrinology/Metabolic Disorders |
UniBE Contributor: |
Pandey, Amit Vikram |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0731-7085 |
Publisher: |
Pergamon Press |
Language: |
English |
Submitter: |
Amit Vikram Pandey |
Date Deposited: |
25 Aug 2014 12:08 |
Last Modified: |
06 Jan 2023 19:30 |
Publisher DOI: |
10.1016/S0731-7085(99)00021-7 |
PubMed ID: |
10704024 |
Uncontrolled Keywords: |
Hemozoin, Malaria, Plasmodium, Hemoglobin, Heme, Chloroquine |
BORIS DOI: |
10.7892/boris.41751 |
URI: |
https://boris.unibe.ch/id/eprint/41751 |
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