Angiotensin I-converting enzyme-gene-polymorphism: relationship to albumin excretion and blood pressure in pediatric patients with type-I-diabetes mellitus

Pavlovic, Mladen; Reile, M.; Haeberle, U.; Schwarz, K.; Heinze, E.; Teller, W.; Lang, D.; Holl, R. W. (1997). Angiotensin I-converting enzyme-gene-polymorphism: relationship to albumin excretion and blood pressure in pediatric patients with type-I-diabetes mellitus. Experimental and clinical endocrinology & diabetes, 105(5), pp. 248-253. Thieme 10.1055/s-0029-1211761

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The purpose of this study was the evaluation of a predictive genetic marker for nephropathy and hypertension in patients with type-I-diabetes mellitus (IDDM). The study was performed on 247 pediatric patients with IDDM. The mean age was 15.5 years (range 3.1-29.3), the mean duration of diabetes was 7.6 years (range 0.1-25.7). Age-related blood pressure and nocturnal albumin excretion rate were compared with the insertion/deletion-(I/D) polymorphism of the angiotensin-I converting enzyme gene. The genotype distribution did not differ significantly between IDDM patients (ID 48%, D 28%, I 24%) and the control group (ID 44%, D 37%, I 19%). Neither in the entire group, nor in patients with IDDM for more than 5 years, was a correlation found bet-ween allele distribution and albumin excretion rate. No correlation was found between genotype and blood pressure. When patients with a chronological age above 12 years were analysed separately, the genotype distribution between the groups with normal and elevated blood pressure showed no significant difference. The previously reported association of the I/D-polymorphism with nephropathy could not be confirmed in this study. The development of microalbuminuria, nephropathy and hypertension will be followed in our pediatric patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Pavlovic, Mladen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0947-7349

Publisher:

Thieme

Language:

English

Submitter:

Mladen Pavlovic

Date Deposited:

05 Jun 2014 11:11

Last Modified:

05 Jun 2014 11:11

Publisher DOI:

10.1055/s-0029-1211761

PubMed ID:

9354852

URI:

https://boris.unibe.ch/id/eprint/41766

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