Subclinical thyroid dysfunction and functional capacity among elderly

Virgini, Vanessa Sophie; Wijsman, Liselotte W; Rodondi, Nicolas; Bauer, Douglas C; Kearney, Patricia M; Gussekloo, Jacobijn; den Elzen, Wendy P J; Jukema, J Wouter; Westendorp, Rudi G J; Ford, Ian; Stott, David J; Mooijaart, Simon P (2014). Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid, 24(2), pp. 208-214. Mary Ann Liebert 10.1089/thy.2013.0071

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Background: Subclinical thyroid dysfunction is common among older people and has been associated with decreased functional capacity but with conflicting data. The aim of this study was to assess the association between subclinical thyroid dysfunction and functional capacity in an elderly population. Methods: We included 5182 participants with a mean age of 75.2 years from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Self-reported functional capacity was assessed using the Barthel Index (BI) and the Instrumental Activities of Daily Living (IADL) scores at baseline and during follow-up. Participants with subclinical hyperthyroidism (n=65) and subclinical hypothyroidism (n=173) were compared to euthyroid participants (n=4944). The association between persistent subclinical thyroid dysfunction and functional capacity and decline was also investigated. Results: At baseline, compared to euthyroid participants (BI 19.73±SE 0.06; IADL 13.52±0.02), there was no difference in functional capacity for participants with subclinical hyperthyroidism (BI 19.60±0.09; IADL 13.51±0.12, p>0.05) or subclinical hypothyroidism (BI 19.82±0.06; IADL 13.55±0.08, p>0.05). Over a mean 3.2-year follow-up period, there was no association between thyroid function and annual decline of either BI or IADL (p>0.05). No association was found between persistent subclinical thyroid dysfunction and functional capacity at baseline or during follow-up (p>0.05). Results were similar after excluding participants with a maximum BI and/or IADL score at baseline. Conclusion: Among well-functioning community-dwelling elderly, we found no evidence that subclinical thyroid dysfunction contributes to decreased functional capacity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Virgini, Vanessa Sophie and Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1050-7256

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

06 Oct 2014 17:30

Last Modified:

23 Jun 2015 15:26

Publisher DOI:

10.1089/thy.2013.0071

PubMed ID:

23941540

BORIS DOI:

10.7892/boris.41776

URI:

https://boris.unibe.ch/id/eprint/41776

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