Reinfection by untreated partners of people treated for Chlamydia trachomatis and Neisseria gonorrhoeae: mathematical modelling study

Low, Nicola; Heijne, Janneke Cornelia Maria; Herzog, Sereina Annik; Althaus, Christian Lorenz (2014). Reinfection by untreated partners of people treated for Chlamydia trachomatis and Neisseria gonorrhoeae: mathematical modelling study. Sexually transmitted infections, 90(3), pp. 254-6. BMJ Publishing Group 10.1136/sextrans-2013-051279

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OBJECTIVES Reinfection after treatment for Chlamydia trachomatis or Neisseria gonorrhoeae reduces the effect of control interventions. We explored the impact of delays in treatment of current partners on the expected probability of reinfection of index cases using a mathematical model. METHODS We used previously reported parameter distributions to calculate the probability that index cases would be reinfected by their untreated partners. We then assumed different delays between index case and partner treatment to calculate the probabilities of reinfection. RESULTS In the absence of partner treatment, the medians of the expected reinfection probabilities are 19.4% (IQR 9.2-31.6%) for C trachomatis and 12.5% (IQR 5.6-22.2%) for N gonorrhoeae. If all current partners receive treatment 3 days after the index case, the expected reinfection probabilities are 4.2% (IQR 2.1-6.9%) for C trachomatis and 5.5% (IQR 2.6-9.5%) for N gonorrhoeae. CONCLUSIONS Quicker partner referral and treatment can substantially reduce reinfection rates for C trachomatis and N gonorrhoeae by untreated partners. The formula we used to calculate reinfection rates can be used to inform the design of randomised controlled trials of novel partner notification technologies like accelerated partner therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Low, Nicola; Min-Heijne, Janneke; Herzog, Sereina and Althaus, Christian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1368-4973

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

26 Mar 2014 13:45

Last Modified:

12 Dec 2014 19:44

Publisher DOI:

10.1136/sextrans-2013-051279

PubMed ID:

24448560

Uncontrolled Keywords:

CHLAMYDIA TRACHOMATIS MATHEMATICAL MODEL NEISSERIA GONORRHOEA PARTNER NOTIFICATION

BORIS DOI:

10.7892/boris.41848

URI:

https://boris.unibe.ch/id/eprint/41848

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