Severe aortic stenosis and coronary artery disease

Stefanini, Giulio; Stortecky, Stefan; Meier, Bernhard; Windecker, Stephan; Wenaweser, Peter Martin (2013). Severe aortic stenosis and coronary artery disease. EuroIntervention, 9 Suppl, S63-S68. Europa Digital & Publishing 10.4244/EIJV9SSA12

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Coronary artery disease (CAD) and aortic stenosis (AS) share pathophysiological mechanisms and risk factors. Moreover, the prevalence of CAD increases among elderly patients with severe AS since disease progression is strongly associated with age for both CAD and AS. These factors contribute to the frequent coexistence of CAD and AS. Patients with concomitant AS and CAD are characterised by higher baseline risk profiles with a larger number of comorbidities as compared to patients with isolated AS. Therefore, adequate therapeutic strategies are crucial for the treatment of these patients. The number of patients undergoing concomitant coronary artery bypass grafting (CABG) and surgical aortic valve replacement (SAVR) doubled during the last decade. Moreover, the development and rapid integration of transcatheter aortic valve implantation (TAVI) into clinical practice in western European countries has further extended invasive treatment of AS to elderly high-risk patients not considered suitable candidates for SAVR, frequently presenting with CAD. The aim of this review article is to provide an overview on CAD prevalence, impact on clinical outcomes, and treatment strategies in patients with severe AS requiring SAVR or TAVI.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Stefanini, Giulio; Stortecky, Stefan; Meier, Bernhard; Windecker, Stephan and Wenaweser, Peter Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1774-024X

Publisher:

Europa Digital & Publishing

Language:

English

Submitter:

Stefan Stortecky

Date Deposited:

24 Feb 2014 10:44

Last Modified:

26 Jun 2016 01:46

Publisher DOI:

10.4244/EIJV9SSA12

PubMed ID:

24025960

URI:

https://boris.unibe.ch/id/eprint/41947

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