Indocyanine Green Loaded Biocompatible Nanoparticles: Stabilisation of Indocyanine Green (ICG) Using Biocompatible Silica-Poly (&epsilon-Caprolactone) Grafted Nanocomposites

Schönbächler, Andrea; Glaied, Olfa; Huwyler, Jörg; Frenz, Martin; Pieles, Uwe (2013). Indocyanine Green Loaded Biocompatible Nanoparticles: Stabilisation of Indocyanine Green (ICG) Using Biocompatible Silica-Poly (&epsilon-Caprolactone) Grafted Nanocomposites. Journal of Photochemistry and Photobiology A: Chemistry, 261, pp. 12-19. Elsevier 10.1016/j.jphotochem.2013.03.010

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Indocyanine green (ICG) is a chemically labile compound which needs to be stabilized in aqueous media to be used in biomedical applications. In the present study, poly(ε-caprolactone) (PCL), a semi-crystalline polyester, was used to encapsulate and stabilize ICG in a hydrophobic environment. A hydrophobic and biocompatible nanocomposite was obtained by the process of encapsulating inorganic silica. ICG was embedded in the hydrophobic polymer coating by starting from a well-defined silica (Si) core of either 80 nm or 120 nm diameter, which served as a template for a ‘grafting from’ approach using ε-caprolactone. The obtained nanocomposite Si grafted PCL/ICG was based on silica nanoparticles grafted with PCL, in which ICG was adsorbed. The nanoparticles were characterized by IR spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The change in the surface charge and the colloidal stability of the nanoparticles was followed by zeta potential measurements. This approach of synthesizing nanocomposite-based ICG demonstrates a new route to stabilize ICG. We synthesized biocompatible nanoparticles containing a high ICG concentration and exhibiting excellent stability to aqueous decomposition.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics

UniBE Contributor:

Frenz, Martin

Subjects:

600 Technology > 620 Engineering

ISSN:

1010-6030

Publisher:

Elsevier

Language:

English

Submitter:

Martin Frenz-Lips

Date Deposited:

03 Jun 2014 09:51

Last Modified:

05 Oct 2015 09:08

Publisher DOI:

10.1016/j.jphotochem.2013.03.010

BORIS DOI:

10.7892/boris.42072

URI:

https://boris.unibe.ch/id/eprint/42072

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