Pathogenesis of AF: impact on intracardiac signals

Shah, Ashok J.; Dubois, Rémi; Miyazaki, Shinsuke; Jadidi, Amir S.; Scherr, Daniel; Wilton, Stephen B.; Roten, Laurent; Pascale, Patrizio; Pedersen, Michala; Derval, Nicolas; Knecht, Sebastien; Sacher, Frederic; Jais, Pierre; Narayan, Sanjiv; Hocini, Meleze; Haïssaguerre, Michel (2011). Pathogenesis of AF: impact on intracardiac signals. IEEE Engineering in Medicine and Biology Society conference proceedings, 2011, pp. 5523-5526. IEEE Service Center 10.1109/IEMBS.2011.6091409

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Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for the highest number of rhythm-related disorders and cardioembolic strokes worldwide. Intracardiac signal analysis during the onset of paroxysmal AF led to the discovery of pulmonary vein as a triggering source of AF, which has led to the development of pulmonary vein ablation--an established curative therapy for drug-resistant AF. Complex, multicomponent and rapid electrical activity widely involving the atrial substrate characterizes persistent/permanent AF. Widespread nature of the problem and complexity of signals in persistent AF reduce the success rate of ablation therapy. Although signal processing applied to extraction of relevant features from these complex electrograms has helped to improve the efficacy of ablation therapy in persistent/permanent AF, improved understanding of complex signals should help to identify sources of AF and further increase the success rate of ablation therapy.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Roten, Laurent


600 Technology > 610 Medicine & health




IEEE Service Center




Laurent Roten

Date Deposited:

06 Jun 2014 12:50

Last Modified:

06 Jun 2014 12:50

Publisher DOI:


PubMed ID:



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