Electrocardiographic PR interval and adverse outcomes in older adults: the Health, Aging, and Body Composition study

Magnani, Jared W.; Wang, Na; Nelson, Kerrie P.; Connelly, Stephanie; Deo, Rajat; Rodondi, Nicolas; Schelbert, Erik B.; Garcia, Melissa E.; Phillips, Caroline L.; Shlipak, Michael G.; Harris, Tamara B.; Ellinor, Patrick T.; Benjamin, Emelia J. (2013). Electrocardiographic PR interval and adverse outcomes in older adults: the Health, Aging, and Body Composition study. Circulation - arrhythmia and electrophysiology, 6(1), pp. 84-90. Lippincott Williams & Wilkins 10.1161/CIRCEP.112.975342

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BACKGROUND

The electrocardiographic PR interval increases with aging, differs by race, and is associated with atrial fibrillation (AF), pacemaker implantation, and all-cause mortality. We sought to determine the associations between PR interval and heart failure, AF, and mortality in a biracial cohort of older adults.

METHODS AND RESULTS

The Health, Aging, and Body Composition (Health ABC) Study is a prospective, biracial cohort. We used multivariable Cox proportional hazards models to examine PR interval (hazard ratios expressed per SD increase) and 10-year risks of heart failure, AF, and all-cause mortality. Multivariable models included demographic, anthropometric, and clinical variables in addition to established cardiovascular risk factors. We examined 2722 Health ABC participants (aged 74±3 years, 51.9% women, and 41% black). We did not identify significant effect modification by race for the outcomes studied. After multivariable adjustment, every SD increase (29 ms) in PR interval was associated with a 13% greater 10-year risk of heart failure (95% confidence interval, 1.02-1.25) and a 13% increased risk of incident AF (95% confidence interval, 1.04-1.23). PR interval >200 ms was associated with a 46% increased risk of incident heart failure (95% confidence interval, 1.11-1.93). PR interval was not associated with increased all-cause mortality.

CONCLUSIONS

We identified significant relationships of PR interval to heart failure and AF in older adults. Our findings extend prior investigations by examining PR interval and associations with adverse outcomes in a biracial cohort of older men and women.

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