The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomized, double-blind, placebo-controlled pilot clinical study. Part 2: mandibular fractures in 59 patients

Schaller, Benoit; Soong, Poh Luon; Zix, Jürgen; Iizuka, Tateyuki; Lieger, Olivier (2013). The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomized, double-blind, placebo-controlled pilot clinical study. Part 2: mandibular fractures in 59 patients. British journal of oral & maxillofacial surgery, 51(8), pp. 803-807. Elsevier 10.1016/j.bjoms.2013.08.008

[img] Text
The role of postoperative prophyactic antibiotic part 2.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (162kB) | Request a copy

The aim of this study was to evaluate the difference between a 5-day and a 1-day postoperative course of antibiotic on the incidence of infection after mandibular fractures involving the alveolus. Sixty-two patients with fractures of the mandible involving the dentoalveolar region were randomly assigned to 2 groups, both of which were given amoxicillin/clavulanic acid 1.2 g intravenously every 8 h from admission until 24 h postoperatively. The 5-day group were then given amoxicillin/clavulanic acid 625 mg orally every 8 h for another 4 days. The 1-day group was given an oral placebo at the same intervals. Follow-up appointments were 1, 2, 4, 6, 12 weeks and 6 months postoperatively. Development of an infection was the primary end point. Fifty-nine of the 62 patients completed this study. Six of the 30 patients in the 5-day group (20%) and 6 out of the 29 in the 1-day group (21%) developed local wound infections. Three of the 6 in the 1-day group developed purulent discharge and swelling. One patient in the 5-day group developed a rash on the trunk. There were no significant differences in the incidence of infection or side effects between the groups. In fractures of the mandible involving the alveolus, a 1-day postoperative course of antibiotic is as effective in preventing infective complications as a 5-day regimen.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Schaller, Benoît; Zix, Jürgen; Iizuka, Tateyuki and Lieger, Olivier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0266-4356

Publisher:

Elsevier

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

03 Apr 2014 08:25

Last Modified:

05 Nov 2015 11:49

Publisher DOI:

10.1016/j.bjoms.2013.08.008

PubMed ID:

24012053

BORIS DOI:

10.7892/boris.42627

URI:

https://boris.unibe.ch/id/eprint/42627

Actions (login required)

Edit item Edit item
Provide Feedback