Reduced estimated GFR and cancer mortality.

Iff, Samuel; Craig, Jonathan C; Turner, Robin; Chapman, Jeremy R; Wang, Jie J; Mitchell, Paul; Wong, Germaine (2014). Reduced estimated GFR and cancer mortality. American Journal of Kidney Diseases, 63(1), pp. 23-30. W.B. Saunders 10.1053/j.ajkd.2013.07.008

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BACKGROUND

Chronic kidney disease is associated with an increased risk of cancer, but whether reduced kidney function also leads to increased cancer mortality is uncertain. The aim of our study was to assess the independent effects of reduced kidney function on the risk of cancer deaths.

STUDY DESIGN

Prospective population-based cohort study.

SETTING & PARTICIPANTS

Participants of the Blue Mountains Eye Study (n=4,077; aged 49-97 years).

PREDICTOR

Estimated glomerular filtration rate (eGFR).

OUTCOMES

Overall and site-specific cancer mortality.

RESULTS

During a median follow-up of 12.8 (IQR, 8.6-15.8) years, 370 cancer deaths were observed in our study cohort. For every 10-mL/min/1.73 m(2) reduction in eGFR, there was an increase in cancer-specific mortality of 18% in the fully adjusted model (P<0.001). Compared with participants with eGFR ≥ 60 mL/min/1.73 m(2), the adjusted HR for cancer-specific mortality for those with eGFR<60 mL/min/1.73 m(2) was 1.27 (95% CI, 1.00-1.60; P=0.05). This excess cancer mortality varied with site, with the greatest risk for breast and urinary tract cancer deaths (adjusted HRs of 1.99 [95% CI, 1.05-3.85; P=0.01] and 2.54 [95% CI, 1.02-6.44; P=0.04], respectively).

LIMITATIONS

Residual confounding, such as from unmeasured socioeconomic factors and the potential effects of erythropoiesis-stimulating agents on cancer deaths, may have occurred.

CONCLUSIONS

eGFR<60 mL/min/1.73m(2) appears to be a significant risk factor for death from cancer. These effects appear to be site specific, with breast and urinary tract cancers incurring the greatest risk of death among those with reduced kidney function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Iff, Samuel

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0272-6386

Publisher:

W.B. Saunders

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

19 Mar 2014 18:11

Last Modified:

05 Dec 2022 14:29

Publisher DOI:

10.1053/j.ajkd.2013.07.008

PubMed ID:

23993153

Uncontrolled Keywords:

Cancer chronic kidney disease estimated glomerular filtration rate mortality survival analyses

BORIS DOI:

10.7892/boris.42675

URI:

https://boris.unibe.ch/id/eprint/42675

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