Experimentally induced cam impingement in the sheep hip

Siebenrock, Klaus A.; Fiechter, Ruth; Tannast, Moritz; Mamisch, Tallal C.; von Rechenberg, Brigitte (2013). Experimentally induced cam impingement in the sheep hip. Journal of orthopaedic research, 31(4), pp. 580-587. Wiley 10.1002/jor.22273

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Sheep hips have a natural non-spherical femoral head similar to a cam-type deformity in human beings. By performing an intertrochanteric varus osteotomy, cam-type femoro-acetabular impingement (FAI) during flexion can be created. We tested the hypotheses that macroscopic lesions of the articular cartilage and an increased Mankin score (MS) can be reproduced by an experimentally induced cam-type FAI in this ovine in vivo model. Furthermore, we hypothesized that the MS increases with longer ambulatory periods. Sixteen sheep underwent unilateral intertrochanteric varus osteotomy of the hip with the non-operated hip as a control. Four sheep were sacrificed after 14, 22, 30, and 38-weeks postoperatively. We evaluated macroscopic chondrolabral alterations, and recorded the MS, based on histochemical staining, for each ambulatory period. A significantly higher prevalence of macroscopic chondrolabral lesions was found in the impingement zone of the operated hips. The MS was significantly higher in the acetabular/femoral cartilage of the operated hips. Furthermore, these scores increased as the length of the ambulatory period increased. Cam-type FAI can be induced in an ovine in vivo model. Localized chondrolabral degeneration of the hip, similar to that seen in humans (Tannast et al., Clin Orthop Relat Res 2008; 466: 273-280; Beck et al., J Bone Joint Surg Br 2005; 87: 1012-1018), can be reproduced. This experimental sheep model can be used to study cam-type FAI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Siebenrock, Klaus-Arno; Tannast, Moritz and Mamisch, Tallal Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0736-0266

Publisher:

Wiley

Language:

English

Submitter:

Stephanie Schmutz

Date Deposited:

04 Apr 2014 11:08

Last Modified:

04 Apr 2014 11:08

Publisher DOI:

10.1002/jor.22273

PubMed ID:

23447499

URI:

https://boris.unibe.ch/id/eprint/42678

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