The transpedicular approach as an alternative route for intervertebral disc regeneration

Vadalà, Gianluca; Russo, Fabrizio; Pattappa, Girish; Schiuma, Damiano; Peroglio, Marianna; Benneker, Lorin M.; Grad, Sibylle; Alini, Mauro; Denaro, Vincenzo (2013). The transpedicular approach as an alternative route for intervertebral disc regeneration. Spine, 38(6), E319-E324. Lippincott Williams & Wilkins 10.1097/BRS.0b013e318285bc4a

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STUDY DESIGN Descriptive anatomical study on ovine and human cadaveric lumbar spinal segments. OBJECTIVE To describe the alternative transpedicular approach to deliver therapeutic agents into intervertebral disc (IVD). SUMMARY OF BACKGROUND DATA The present delivery approach of therapeutic agents (growth factors/cells/hydrogels) within the IVD is through injection, via the annulus fibrosus (AF). However, it has recently been demonstrated that small needle puncture of the AF leads to further degeneration and disc herniation. In addition, the injected material has a high chance to be extruded through the AF injury. METHODS Lumbar ovine and human spinal segments were used. Under fluoroscopy, a 2-mm Kirschner wire was introduced in the caudal vertebra through the pedicle and the inferior endplate to the nucleus pulposus. Gross anatomy analysis and high-resolution peripheral quantitative computed tomography (HR-pQCT) were performed to assess the right position of the wire in pedicles. Discography and nucleotomy were performed using a 14G cannula insertion or a 2-mm arthroscopic shaver blade, respectively. Nucleoplasty was also performed with agarose gel/contrast agent and imaged with HR-pQCT. RESULTS Gross anatomy, fluoroscopy, and HR-pQCT images showed that the nucleus pulposus could be approached through the endplate via the pedicle without affecting the spinal canal and the neural foramina. The contrast agent was delivered into the IVD and nucleus pulposus was removed from the disc and filled with agarose gel. CONCLUSION This study describes how a transpedicular approach can be used as an alternative route to deliver therapeutic agents to the disc without disruption of the AF showing the potential use of this technique in preclinical research and highlighting its clinical relevance for IVD regeneration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Benneker, Lorin Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0362-2436

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Stephanie Schmutz

Date Deposited:

08 Apr 2014 10:47

Last Modified:

08 Apr 2014 10:47

Publisher DOI:

10.1097/BRS.0b013e318285bc4a

PubMed ID:

23324932

URI:

https://boris.unibe.ch/id/eprint/42823

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