Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1

Amann, Ruth; Trueb, Beat (2013). Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. International journal of molecular medicine, 32(5), pp. 983-988. Spandidos Publications 10.3892/ijmm.2013.1484

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Fibroblast growth factor (FGF) receptor-like protein 1 (FGFRL1) is a recently discovered member of the FGF receptor (FGFR) family. Similar to the classical FGFRs, it contains three extracellular immunoglobulin-like domains and interacts with FGF ligands. However, in contrast to the classical receptors, it does not contain any intracellular tyrosine kinase domain and consequently cannot signal by transphosphorylation. In mouse kidneys, FgfrL1 is expressed primarily at embryonic stages E14-E15 in regions where nascent nephrons develop. In this study, we used whole-mount in situ hybridization to show the spatial pattern of five different Fgfrs in the developing mouse kidney. We compared the expression pattern of FgfrL1 with that of other Fgfrs. The expression pattern of FgfrL1 closely resembled that of Fgfr1, but clearly differed from that of Fgfr2‑Fgfr4. It is therefore conceivable that FgfrL1 signals indirectly via Fgfr1. The mechanisms by which FgfrL1 affects the activity of Fgfr1 remain to be elucidated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology > Rheumatology (discontinued)
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Amann, Ruth and Trueb, Beat

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1107-3756

Publisher:

Spandidos Publications

Language:

English

Submitter:

Stefan Kuchen

Date Deposited:

01 Apr 2014 14:15

Last Modified:

13 Dec 2014 09:32

Publisher DOI:

10.3892/ijmm.2013.1484

PubMed ID:

24026051

BORIS DOI:

10.7892/boris.42840

URI:

https://boris.unibe.ch/id/eprint/42840

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