Orthostatic hypotension in Parkinson's disease: association with cognitive decline?

Allcock, Liesl M.; Kenny, Rose Anne; Mosimann, Urs Peter; Tordoff, Sherley; Wesnes, Keith A.; Hildreth, Anthony J.; Burn, David J. (2006). Orthostatic hypotension in Parkinson's disease: association with cognitive decline? International journal of geriatric psychiatry, 21(8), pp. 778-783. Wiley-Blackwell 10.1002/gps.1562

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BACKGROUND Orthostatic hypotension is common in Lewy body disorders and may be related to disease progression and the spread of Lewy body pathology. We therefore hypothesize that PD patients with orthostatic hypotension (OH) have a different cognitive profile compared to PD patients without OH. METHODS This cross-sectional study included 175 PD patients. Blood pressure (BP) was measured with a validated digital blood pressure monitor and patients with a systolic BP drop of > or =20 mmHg or a systolic pressure of <90 mm Hg after standing were considered to have OH. Cognition was assessed using MMSE extended by a selection of computerized cognitive tests focusing on reaction time, sustained attention, working memory and episodic verbal and visual memory. RESULTS Eighty-seven (49.7%) of the PD patients had OH. These patients were significantly more impaired in sustained attention and visual episodic memory compared to PD patients without OH. CONCLUSION We conclude that there are differences in the neuropsychological performance of patients with PD and OH, supporting the hypothesis that OH might be a marker for disease progression and cognitive decline in PD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Mosimann, Urs Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0885-6230

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Pascal Wurtz

Date Deposited:

11 Jul 2014 10:49

Last Modified:

11 Jul 2014 10:49

Publisher DOI:

10.1002/gps.1562

PubMed ID:

16906622

Uncontrolled Keywords:

orthostatic hypotension, cognitive deficits, Parkinson's disease

URI:

https://boris.unibe.ch/id/eprint/43029

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