Visual perception in Parkinson disease dementia and dementia with Lewy bodies

Mosimann, Urs P.; Mather, G.; Wesnes, K. A.; O'Brien, J. T.; Burn, D. J.; McKeith, I. G. (2004). Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology, 63(11), pp. 2091-2096. Lippincott Williams & Wilkins 10.1212/01.WNL.0000145764.70698.4E

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OBJECTIVE To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). METHODS The authors used a cross-sectional study to compare three demented groups matched for overall dementia severity (PDD: n = 24; DLB: n = 20; AD: n = 23) and two age-, sex-, and education-matched control groups (PD: n = 24, normal controls [NC]: n = 25). RESULTS Visual perception was globally more impaired in PDD than in nondemented controls (NC, PD), but was not different from DLB. Compared to AD, PDD patients tended to perform worse in all perceptual scores. Visual perception of patients with PDD/DLB and visual hallucinations was significantly worse than in patients without hallucinations. CONCLUSIONS Parkinson disease dementia (PDD) is associated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consistent with previous neuroimaging studies reporting hypoactivity in cortical areas involved in visual processing in PDD and DLB.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Mosimann, Urs Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0028-3878

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Pascal Wurtz

Date Deposited:

18 Jul 2014 10:52

Last Modified:

05 Dec 2014 13:16

Publisher DOI:

10.1212/01.WNL.0000145764.70698.4E

PubMed ID:

15596755

BORIS DOI:

10.7892/boris.43035

URI:

https://boris.unibe.ch/id/eprint/43035

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