Visual exploration behaviour during clock reading in Alzheimer's disease

Mosimann, U. P.; Felblinger, J.; Ballinari, P.; Hess, C. W.; Müri, R. M. (2004). Visual exploration behaviour during clock reading in Alzheimer's disease. Brain, 127(2), pp. 431-438. Oxford University Press 10.1093/brain/awh051

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Eye movement behaviour during visual exploration of 24 patients with probable Alzheimer's disease and 24 age-matched controls was compared in a clock reading task. Controls were found to focus exploration on distinct areas at the end of each clock hand. The sum of these two areas of highest fixation density was defined as the informative region of interest (ROI). In Alzheimer's disease patients, visual exploration was less focused, with fewer fixations inside the ROI, and the time until the first fixation was inside the ROI was significantly delayed. Changes of fixation distribution correlated significantly with the ability to read the clock correctly, but did not correlate with dementia severity. In Alzheimer's disease patients, fixations were longer and saccade amplitudes were smaller. The altered visual exploration in Alzheimer's disease might be related to parietal dysfunction or to an imbalance between a degraded occipito-parietal and relatively preserved occipito-temporal visual network.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine
07 Faculty of Human Sciences > Institute of Psychology > Cognitive Psychology, Perception and Methodology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik

UniBE Contributor:

Ballinari, Pietro; Hess, Christian Walter and Müri, René Martin


600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology




Oxford University Press




Pascal Wurtz

Date Deposited:

11 Apr 2014 14:03

Last Modified:

24 Oct 2019 18:18

Publisher DOI:


PubMed ID:





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