Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades.

Wipfli, M.; Felblinger, J.; Mosimann, U. P.; Hess, C. W.; Schläpfer, T. E.; Müri, R. M. (2001). Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades. European journal of neuroscience, 14(3), pp. 571-575. Blackwell Science 10.1046/j.0953-816x.2001.01671.x

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The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Hess, Christian Walter; Schläpfer, Thomas E. and Müri, René Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0953-816X

Publisher:

Blackwell Science

Language:

English

Submitter:

Pascal Wurtz

Date Deposited:

18 Jul 2014 10:14

Last Modified:

18 Jul 2014 10:14

Publisher DOI:

10.1046/j.0953-816x.2001.01671.x

PubMed ID:

11553308

URI:

https://boris.unibe.ch/id/eprint/43044

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