Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors

Engelen, Lian; Ferreira, Isabel; Stehouwer, Coen D; Boutouyrie, Pierre; Laurent, Stéphane; Allemann, Yves; Hutter, Damian; Rimoldi, Stefano; Rexhaj, Emrush; Sartori, Claudio; Scherrer, Urs (2013). Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors. European Heart Journal, 34(30), pp. 2368-80. Oxford University Press 10.1093/eurheartj/ehs380

Full text not available from this repository. (Request a copy)

AIMS Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures. METHODS AND RESULTS We combined CCIMT data obtained by echotracking on 24 871 individuals (53% men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted ('normal') values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized βs 0.19 (95% CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)]. CONCLUSION We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Allemann, Yves; Hutter, Damian; Rimoldi, Stefano; Rexhaj, Emrush; Sartori, Claudio and Scherrer, Urs

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

03 Mar 2014 12:00

Last Modified:

11 Aug 2015 11:36

Publisher DOI:

10.1093/eurheartj/ehs380

PubMed ID:

23186808

Uncontrolled Keywords:

Ageing, Atherosclerois, Carotid intima-media thickness, Echotracking, Reference intervals, Risk factors

URI:

https://boris.unibe.ch/id/eprint/43130

Actions (login required)

Edit item Edit item
Provide Feedback