The ins and outs of phosphatidylethanolamine synthesis in Trypanosoma brucei.

Farine, Luce; Bütikofer, Peter (2013). The ins and outs of phosphatidylethanolamine synthesis in Trypanosoma brucei. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1831(3), pp. 533-542. Elsevier 10.1016/j.bbalip.2012.09.008

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Phospholipids are not only major building blocks of biological membranes but fulfill a wide range of critical functions that are often widely unrecognized. In this review, we focus on phosphatidylethanolamine, a major glycerophospholipid class in eukaryotes and bacteria, which is involved in many unexpected biological processes. We describe (i) the ins, i.e. the substrate sources and biochemical reactions involved in phosphatidylethanolamine synthesis, and (ii) the outs, i.e. the different roles of phosphatidylethanolamine and its involvement in various cellular events. We discuss how the protozoan parasite, Trypanosoma brucei, has contributed and may contribute in the future as eukaryotic model organism to our understanding of phosphatidylethanolamine homeostasis. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Farine, Luce and Bütikofer, Peter

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1388-1981

Publisher:

Elsevier

Language:

English

Submitter:

Patrizia Catucci

Date Deposited:

04 Jul 2014 10:49

Last Modified:

29 May 2017 18:06

Publisher DOI:

10.1016/j.bbalip.2012.09.008

PubMed ID:

23010476

URI:

https://boris.unibe.ch/id/eprint/43262

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