Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins.

Montalbetti, Nicolas; Dalghi Gens, Marianela Gisela; Albrecht, Christiane; Hediger, Matthias (2014). Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins. Journal of mammary gland biology and neoplasia, 19(1), pp. 73-90. Springer 10.1007/s10911-014-9317-9

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Milk nutrients are secreted by epithelial cells in the alveoli of the mammary gland by several complex and highly coordinated systems. Many of these nutrients are transported from the blood to the milk via transcellular pathways that involve the concerted activity of transport proteins on the apical and basolateral membranes of mammary epithelial cells. In this review, we focus on transport mechanisms that contribute to the secretion of calcium, trace minerals and water soluble vitamins into milk with particular focus on the role of transporters of the SLC series as well as calcium transport proteins (ion channels and pumps). Numerous members of the SLC family are involved in the regulation of essential nutrients in the milk, such as the divalent metal transporter-1 (SLC11A2), ferroportin-1 (SLC40A1) and the copper transporter CTR1 (SLC31A1). A deeper understanding of the physiology and pathophysiology of these transporters will be of great value for drug discovery and treatment of breast diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Montalbetti, Nicolas; Dalghi Gens, Marianela Gisela; Albrecht, Christiane and Hediger, Matthias

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1083-3021

Publisher:

Springer

Language:

English

Submitter:

Patrizia Catucci

Date Deposited:

22 Jul 2014 17:34

Last Modified:

11 Nov 2015 13:44

Publisher DOI:

10.1007/s10911-014-9317-9

PubMed ID:

24567109

BORIS DOI:

10.7892/boris.43277

URI:

https://boris.unibe.ch/id/eprint/43277

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